Ageing population is steeply increasing worldwide. A consequence of age related decline is the clinical condition of frailty. Frailty is a biological syndrome of decreased reserve and resistance to stressors, resulting from cumulative declines across multiple physiologic systems and causing vulnerability to adverse outcomes. Susceptibility to stressors is influenced by biological, behavioral, environmental, and social risk factors, with the main consequence being an increased risk for multiple adverse health outcomes, including disability, morbidity, falls, hospitalization, institutionalization, and death. However, frailty is a dynamic and not an irreversible process; it seems preventable, may be delayed, or reversed. Our understanding of frailty has markedly improved over the last five years, yet there are many issues yet to be resolved. FrailSafe aims to better understand frailty and its relation to co-morbidities; to identify quantitative and qualitative measures of frailty through advanced data mining approaches on multiparametric data and use them to predict short and long-term outcome and risk of frailty; to develop real life sensing (physical, cognitive, psychological, social) and intervention (guidelines, real-time feedback, Augmented Reality serious games) platform offering physiological reserve and external challenges; to provide a digital patient model of frailty sensitive to several dynamic parameters, including physiological, behavioural and contextual; this model being the key for developing and testing pharmaceutical and non-pharmaceutical interventions; to create “prevent-frailty” evidence-based recommendations for the elderly; to strengthen the motor, cognitive, and other “anti-frailty” activities through the delivery of personalised treatment programmes, monitoring alerts, guidance and education; and to achieve all with a safe, unobtrusive and acceptable system for the ageing population while reducing the cost of health care systems.
FrailSafe Objectives are divided into Medical and Technological Objectives. Medical Objectives are related to the identification of quantitative and qualitative measures of frailty and the associated co-morbidities. The MOs of the project are summarized in the following points:
The first two Medical Objectives (MOs) of the project are to better understand frailty and its relation to co-morbidities and develop quantitative and qualitative measures to define frailty .
The third Medical Objective of the project concerns the use of measures developed in order to predict the short and long-term outcome.
The fourth Medical Objective of the project is to develop real life tools for the assessment of physiological reserve and external challenges .
The fifth Medical Objective of the project is to provide a model sensitive to change in order that will facilitate the testing of pharmaceutical and non-pharmaceutical interventions, which will be designed to delay, arrest or even reverse the transition to frailty, can be tested.
The sixth Medical Objective of the project is to create “prevent-frailty” evidence based recommendations for older people regarding activities of daily living, lifestyle, nutrition, etc. to strengthen the motor, cognitive, and other “anti-frailty” activities through the delivery of personalised treatment programmes, games, monitoring alerts, guidance and education and estimate the influence of these interventions.
The seventh Medical Objective of the project is to achieve all through a safe, unobtrusive and acceptable system for the ageing population while reducing the cost of health care systems.